至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

Int Immunopharmacol. 2020-11; 
Shuangshi Wei, Shengbao Duan, Xiaomei Liu, Hongmei Wang, Shaohua Ding, Yezhou Chen, Jinsong Xie, Jingjing Tian, Nong Yu, Pingju Ge, Xinglin Zhang, Xiaohong Chen, Yong Li, Qinglin Meng
Products/Services Used Details Operation
Monoclonal Antibody Services … generated luminescence. Here, Hela monoclonal cells with overexpressed ACE2 were infected with the lentivirus carrying SARS-CoV-2 spike protein and the luciferase reporter gene (GenScript Co., Nanjing, China). The IgYs … Get A Quote

摘要

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.

关键词

Chicken Egg Yolk Antibodies, IgY, Neutralizing agent, SARS-CoV-2, Spike protein variants