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Comparison of potency assays to assess SARS-CoV-2 neutralizing antibody capacity in COVID-19 convalescent plasma

J Virol Methods. 2020-12; 
Christine von Rhein, Tatjana Scholz, Lisa Henss, Romy Kronstein-Wiedemann, Tatjana Schwarz, Roman N Rodionov, Victor M Corman, Torsten Tonn, Barbara S Schnierle
Products/Services Used Details Operation
Plasmids for SARS-CoV-2 Detection and Research … 2 (ACE2). The RBD of SARS-CoV-2 S protein strongly interacts with hACE2. The SARS-CoV-2 sVNT Kit (Genscript; Leiden, Netherlands) is a blocking ELISA, which mimics this virus receptor binding process. The protein-protein … Get A Quote

摘要

Convalescent plasma is plasma collected from individuals after resolution of an infection and the development of antibodies. Passive antibody administration by transfusion of convalescent plasma is currently in clinical evaluations to treat COVID-19 patients. The level of neutralizing antibodies vary among convalescent patients and fast and simple methods to identify suitable plasma donations are needed. We compared three methods to determine the SARS-CoV-2 neutralizing activity of human convalescent plasma: life virus neutralization by plaque reduction assay, a lentiviral vector based pseudotype neutralization assay and a competition ELISA-based surrogate virus neutralization assay (sVNT). Neutralization activ... More

关键词

Convalescent plasma, Neutralization, Pseudotyping, SARS-CoV-2