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Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function

Int J Biol Macromol. 2020; 
Rui Zhang, Jessika Trower, Tongde Wu
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Recombinant Antibody Expression … downstream applications. 2.2. Detection of protein degradation, antibodies, and immunoblot analysis. Recombinant human BPIFA1 (GenScript) in DPBS (Hyclone) was incubated with HDM at indicated times and concentrations. The … Get A Quote

摘要

Bacterial permeability family member A1 (BPIFA1) is one of the most abundant proteins present in normal airway surface liquid (ASL). It is known to be diminished in asthmatic patients' sputum, which causes airway hyperresponsiveness (AHR). What is currently unclear is how environmental factors, such as allergens' impact on BPIFA1's abundance and functions in the context of allergic asthma. House dust mite (HDM) is a predominant domestic source of aeroallergens. The group of proteases found in HDM is thought to cleave multiple cellular protective mechanisms, and therefore foster the development of allergic asthma. Here, we show that BPIFA1 is cleaved by HDM proteases in a time-, dose-, and temperature-dependent ... More

关键词

BPIFA1, Degradation, HDM