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Computationally validated SARS-CoV-2 CTL and HTL Multi-Patch vaccines, designed by reverse epitomics approach, show potential to cover large ethnically distributed human population worldwide

J Biomol Struct Dyn. 2020-11; 
Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Deepa Agarwal, Ajay Kumar Saxena, Michael Kolbe, Sarman Singh, Ashwin Kotnis, Brijesh Rathi, Seema A Nayar, Ho-Joon Shin, Kapil Vashisht, Kailash C Pandey
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Molecular Biology Tools … already been infected and 870,286 died worldwide, with a mortality rate of ∼3.295% (cases/deaths*100) (WHO Coronavirus Disease (COVID-19) Dashboard … The generated cDNA of all the MPVs was further analyzed by GenScript Rare Codon Analysis Tool for its large … Get A Quote

摘要

The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is responsible for the COVID-19 outbreak. The highly contagious COVID-19 disease has spread to 216 countries in less than six months. Though several vaccine candidates are being claimed, an effective vaccine is yet to come. A novel reverse epitomics approach, 'overlapping-epitope-clusters-to-patches' method is utilized to identify the antigenic regions from the SARS-CoV-2 proteome. These antigenic regions are named as 'Ag-Patch or Ag-Patches', for Antigenic Patch or Patches. The identification of Ag-Patches is based on the clusters of overlapping epitopes rising from SARS-CoV-2 proteins. Further, we have utilized the identified Ag-Patches to desig... More

关键词

Ag-Patch (antigenic patch), COVID-19, Coronavirus, Multi-Epitope Vaccine, Multi-Patch Vaccine, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Toll-Like Receptor (TLR), epitope, overlapping-epitope-clusters-to-patches, reverse epitomics