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Recombinant Antibody Expression> | … We obtained lyophilized Seomae mugwort extract from Namhae Seomae mugwort Agricultural Association Corporation. Jaceosidin and eupatilin were purchased from Cayman Chemical. IL‐1β, IL‐6 and TNF‐α recombinant proteins were purchased from GenScript … | Get A Quote |
Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage destruction in an OA mouse model. In vitro and ex vivo analyses revealed that the extract suppressed MMP3, MMP13, ADAMTS4 and ADAMTS5 expression induced by IL-1β, IL-6 and TNF-α and inhibited the loss of extracellular sulphated proteoglycans. In vivo analysis revealed that oral administration of the extract suppressed DMM-induced cartilage destruction. We identified jaceosidin in Seomae mugwort and showed that this compound decreased MMP3, MMP13, ADAMTS4 and ADAMTS5 expression le... More