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Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice

J Cell Mol Med. 2020; 
Hyemi Lee, Dain Jang, Jimin Jeon, Chanmi Cho, Sangil Choi, Seong Jae Han, Eunjeong Oh, Jiho Nam, Chan Hum Park, Yu Su Shin, Seung Pil Yun, Siyoung Yang, Li-Jung Kang
Products/Services Used Details Operation
Recombinant Antibody Expression … We obtained lyophilized Seomae mugwort extract from Namhae Seomae mugwort Agricultural Association Corporation. Jaceosidin and eupatilin were purchased from Cayman Chemical. IL‐1β, IL‐6 and TNF‐α recombinant proteins were purchased from GenScript Get A Quote

摘要

Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage destruction in an OA mouse model. In vitro and ex vivo analyses revealed that the extract suppressed MMP3, MMP13, ADAMTS4 and ADAMTS5 expression induced by IL-1β, IL-6 and TNF-α and inhibited the loss of extracellular sulphated proteoglycans. In vivo analysis revealed that oral administration of the extract suppressed DMM-induced cartilage destruction. We identified jaceosidin in Seomae mugwort and showed that this compound decreased MMP3, MMP13, ADAMTS4 and ADAMTS5 expression le... More

关键词

IκB, Seomae mugwort, cartilage destruction, jaceosidin, matrix metalloproteinase, nuclear factor-kappa B, osteoarthritis