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A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier Dysfunction

Biomolecules. 2020; 
James A Reihill, Xuan Ouyang, Zhixuan Yang, Lisa E J Douglas, Mei Zhou, Tianbao Chen, S Lorraine Martin
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Recombinant Antibody Expression … detail previously [14,15]. PE-BBI and pLR-HL were synthesised by GenScript (> 98% purity). 2.3. Determination of Putative Protease Inhibitor Potency versus Recombinant Trypsin and CRE TLP Activity. Synthetic replicates of PE … Get A Quote

摘要

Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. The present study sought to evaluate two novel protease inhibitors (PE-BBI and pLR-HL), recently isolated from amphibian skin secretions, for their potential to neutralise cockroach TLP activity and to determine any protective effect on cockroach-induced airway epithelial barrier disruption. Inhibitor potencies against the cockroach-associated activities were determined using a fluorogenic peptide substrate-based activ... More

关键词

airway epithelial barrier, airway epithelial barrier dysfunction, airway epithelium, allergen, cockroach, protease, protease inhibitor