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Nora Virus VP4b and Circulate in Hemolymph of Infected with Coordinate Expression of Vago and Vir-1

Vaccines (Basel). 2020; 
Amanda Macke, Wilfredo Lopez, Darby J Carlson, Kimberly A Carlson
Products/Services Used Details Operation
Recombinant Antibody Expression … per manufacturer's instructions. Recombinant VP4b (prepared as described in [19]) and recombinant Vago and Vir-1 proteins (Genscript, Piscataway, NJ, USA) were used as positive controls during analysis. Whole fly protein … Get A Quote

摘要

Study of the novel RNA virus, Nora virus, which is a persistent, picorna-like virus that replicates in the gut of offers insight into human innate immunity and other picorna-like viruses. Nora virus infection leads to a locomotor abnormality and upregulation of two candidate target proteins, Vago and Virus-induced RNA 1 (Vir-1). These proteins are uncharacterized in response to Nora virus. We hypothesize that Nora virus is circulating in the hemolymph of Nora virus-infected , allowing for migration beyond the primary site of replication in the gut. Analysis by qRT-PCR demonstrated biphasic viral load and corresponding and transcription levels, suggesting transcription of and occurs in response to viral inf... More

关键词

Drosophila melanogaster, Nora virus, Vago, Vir-1, hemolymph, picorna-like virus