| Products/Services Used | Details | Operation |
|---|---|---|
| Custom DNA/RNA Oligos | … 3′-azido-2′, 3′-dideoxythymidine monophosphate (AZTP) was used as received (Jena Bioscience, Germany). The DNA oligomers were purchased from Genscript (EU). 1 H NMR (Nuclear Magnetic Resonance) spectra were recorded on a Bruker AC 400 spectrometer … | Get A Quote |
Nucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate -carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate -carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were ... More
