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Variation in the expression level of MALAT1, MIAT and XIST lncRNAs in coronary artery disease patients with and without type 2 diabetes mellitus

Arch Physiol Biochem. 2020;

Nasim Sohrabifar, Sayyed Mohammad Hossein Ghaderian, Saeed Alipour Parsa, Hamid Ghaedi, Hossein Jafari

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Molecular Biology Tools	… Primers and probes for each gene were designed using GenScript Real-time PCR (TaqMan) Primer Design tool and their sequences and product lengths are listed in Table 2. The relative expression level of each lncRNA after normalisation was evaluated using the 2 −ΔΔCt …	Get A Quote

摘要

: The MALAT1, MIAT, and XIST long noncoding RNAs (lncRNAs) participate in the pathogenesis of complex diseases and also serve as diagnostic markers. The study aimed to assess their expressions in CAD patients with or without T2DM against diabetic and non-diabetic controls.: The expression levels of three lncRNAs in 50 CAD patients (with or without diabetes) and 50 non-CAD subjects (with or without diabetes) were evaluated by using the TaqMan Assay method.: MALAT1 and MIAT were upregulated in CAD patients ( Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients ( Value= .0003). MALAT1 gene had the highest diagnostic power for ... More