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Performance of Treponema pallidum recombinant proteins in the serological diagnosis of syphilis

PLoS ONE. 2020; 
Ângelo Antônio Oliveira Silva, Ueriton Dias de Oliveira, Larissa de Carvalho Medrado Vasconcelos, Leonardo Foti, Leonardo Maia Leony, Ramona Tavares Daltro, Amanda Leitolis, Fernanda Washington de Mendonça Lima, Marco Aurélio Krieger, Nilson Ivo Tonin Zanchin, Fred Luciano Neves Santos
Products/Services Used Details Operation
Recombinant Antibody Expression … sera samples. Recombinant proteins synthesis. Optimized synthetic genes for E. coli expression of T. pallidum subsp. pallidum Nichols strain were acquired from a commercial supplier (GenScript, Piscataway-NJ, USA). The … Get A Quote

摘要

Syphilis serodiagnosis is challenging because distinct clinical forms of the infection may influence serological performance and discordant results between tests make clinical decisions difficult. Several recombinant Treponema pallidum-proteins have already been tested for syphilis diagnosis and they are critical to achieve high accuracy in serological testing. Our aim was to assess the varied from performance of T. pallidum-recombinant proteins TmpA, TpN17 and TpN47 for syphilis serodiagnosis. The proteins were evaluated using sera of 338 T. pallidum-negative, 173 T. pallidum-positive individuals and 209 sera from individuals infected with unrelated diseases. The diagnostic potential was validated by analysis ... More

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