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ERINA is an estrogen-responsive lncRNA that drives breast cancer through the E2F1/RB1 pathway

Cancer Res. 2020; 
Zihui Fang, Yue Wang, Zehua Wang, Meishu Xu, Songrong Ren, Da Yang, Mei Hong, Wen Xie
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Mutagenesis Services … Page 11. 11 The full-length E2F1 plasmid was purchased from GenScript ( NM_005225.3. The E2F1 deletion mutant constructs were kindly provided by Dr. Jiandong Chen from H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA … Get A Quote

摘要

Resistance to therapeutic drugs is a major challenge in the treatment of cancers including breast cancer. Long noncoding RNAs (lncRNA) are known to have diverse physiological and pathophysiological functions, including in cancer. In searching for lncRNA responsible for cancer drug resistance, we identified an intergenic lncRNA ERINA (estrogen inducible lncRNA) as a novel lncRNA highly expressed in multiple cancer types, especially in estrogen receptor (ER)-positive breast cancers. Expression of ERINA was inversely correlated with survival of ER-positive breast cancer patients and sensitivity to CDK inhibitor in breast cancer cell lines. Functional characterization established ERINA as an oncogenic lncRNA, as kn... More

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