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Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Sci Rep. 2020; 
Tatjana Seitz, Kim Freese, Peter Dietrich, Wolfgang Erwin Thasler, Anja Bosserhoff, Claus Hellerbrand
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … Overexpression of FGF9 protein was induced by transfection of a human FGF9 open reading frame (ORF) pcDNA3.1+/C-(K)DYK vector from GenScript (Piscataway, NJ, USA; CAT#: OHu27298) using LipofectAMINE plus method (Life Technologies, Darmstadt, Germany) as … Get A Quote

摘要

Hepatocellular carcinoma (HCC) is closely associated with liver fibrosis. Hepatic stellate cells (HSC) and cancer-associated myofibroblasts are key players in liver fibrogenesis and hepatocarcinogenesis. Overexpression of fibroblast growth factor (FGF) receptors contributes to HCC development and progression. This study aimed to elucidate the role of FGFs in the HSC-HCC crosstalk. Analysis of the expression of the fifteen paracrine FGF-members revealed that FGF9 was only expressed by HSC but not by HCC cells. Also in human HCC tissues, HSC/stromal myofibroblasts were identified as cellular source of FGF9. High expression levels of FGF9 significantly correlated with poor patient survival. Stimulation with recomb... More

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