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A simple protein-based surrogate neutralization assay for SARS-CoV-2

JCI Insight. 2020; 
Kento T Abe, Zhijie Li, Reuben Samson, Payman Samavarchi-Tehrani, Emelissa J Valcourt, Heidi Wood, Patrick Budylowski, Alan P Dupuis Ii, Roxie C Girardin, Bhavisha Rathod, Jenny Wang, Miriam Barrios-Rodiles, Karen Colwill, Allison McGeer, Samira Mubareka, Jennifer L Gommerman, Yves Durocher, Mario Ostrowski, Kathleen A McDonough, Michael A Drebot, Steven J Drews, James M Rini, Anne-Claude Gingras
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GenParts™ DNA Fragments … The RBD and ACE2 constructs contain residues 328-528 (RFPN...CGPK) and 19-615 (STIE...PYAD), respectively. The cDNA of the human CR3022 Fab fragment was synthesized by GenScript based on its previously reported sequence (31) … Get A Quote

摘要

Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcomes has not been completely characterized. Of particular importance is the identification of immune correlates of infection that would support public health decision-making on treatment approaches, vaccination strategies, and convalescent plasma therapy. While ELISA-based assays to detect and quantitate antibodies to SARS-CoV-2 in patient samples have been developed, the detection of neutralizing antibodies typically requires more demanding cell-based viral assays. H... More

关键词

Adaptive immunity, Antigen, Immunoglobulins, Infectious disease