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Human Papillomavirus 16 E7 Promotes EGFR/PI3K/AKT1/NRF2 Signaling Pathway Contributing to PIR/NF-κB Activation in Oral Cancer Cells

Cancers (Basel). 2020-07; 
Diego Carrillo-Beltrán , Juan P Muñoz , Nahir Guerrero-Vásquez , Rancés Blanco , Oscar León , Vanesca de Souza Lino , Julio C Tapia , Edio Maldonado , Karen Dubois-Camacho , Marcela A Hermoso , Alejandro H Corvalán , Gloria M Calaf , Enrique Boccardo , Francisco Aguayo
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ORF cDNA Clones/MolecularCloud For Pirin overexpression, pcDNA 3.1+C–eGFP and pcDNA 3.1+C-eGFP–Pirin vectors were purchased from GenScript Biotech Corp. (Piscataway, NJ, USA). Get A Quote
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摘要

A subset of oral carcinomas is etiologically related to high-risk human papillomavirus (HR-HPV) infection, with HPV16 being the most frequent HR-HPV type found in these carcinomas. The oncogenic role of HR-HPV is strongly dependent on the overexpression of E6 and E7 oncoproteins, which, in turn, induce p53 and pRb degradation, respectively. Additionally, it has been suggested that HR-HPV oncoproteins are involved in the regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), inducing cancer progression and metastasis. Previously, we reported that HPV16 E7 oncoprotein promotes Pirin upregulation resulting in increased epithelial-mesenchymal transition (EMT) and cell migration, with... More

关键词

NF-κB; cancer; oncoprotein; oral; papillomavirus; pirin.