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TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

Neurosci Lett. 2018-06; 
Stephani A Davis , Sheed Itaman , Christopher M Khalid-Janney , Justin A Sherard , James A Dowell , Nigel J Cairns , Michael A Gitcho
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Monoclonal Antibody Services Immunofluorescence of TDP- 43 (C-terminal, 488nm, green), Parkin (Genscript, 555nm, red), Get A Quote

摘要

Transactive response DNA-binding protein of 43 kDa (TDP-43) functions as a heterogeneous nuclear ribonucleoprotein and is the major pathological protein in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis/motor neuron disease (ALS/MND). TDP-43 pathology may also be present as a comorbidity in approximately 20-50% of sporadic Alzheimer's disease cases. In a mouse model of MND, full-length TDP-43 increases association with the mitochondria and blocking the TDP-43/mitochondria interaction ameliorates motor dysfunction. Utilizing a proteomics screen, several mitochondrial TDP-43-interacting partners were identified, including voltage-gated anion channel 1 (VDAC1) and prohibitin 2 (PHB2), a... More

关键词

APP/PS1; MFN2; Mitochondria; Mitophagy; PHB2; PMPCA; TDP-43. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.