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Recombinant Antibody Expression> | … LP17 (LQVTDSGLYRCVIYHPP) was chemically synthesized from GenScript, China (9, 25). To inhibit TREM1, vehicle or LP17 (1 mg/kg) dissolved in ultrapure water was administered intranasally 1 h post-modeling (9). Recombinant TREM-1 (GenScript, China) was intranasally … | Get A Quote |
Neuroinflammation is a key process in the pathogenesis of subarachnoid hemorrhage (SAH) and contributes to poor outcome in patients. The purpose of this study is to explore the effect of triggering receptor expressed on myeloid cells 1 (TREM1) in the SAH, as well as its potential mechanism. In our study, plasma levels of soluble TREM1 was increased significantly after SAH and correlated to SAH severity and serum C-reactiveprotein. TREM1 inhibitory peptide LP17 alleviated the neurological deficits, attenuated brain water content, and reduced neuronal damage after SAH. Meanwhile, TREM1 inhibitory peptide decreased neuroinflammation (evidenced by the decreased levels of markers including IL-6, IL-1β, TNF-α) by a... More