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Mammalian Expression> | … cDNA encoding the GluN2C and GluN2D were purchased from GenScript. Mutated GluN1, 2A and 2B cDNA constructs capable of assembling as GluN1/2A/2B triheteromeric (1/2AB) receptors 37 were obtained from Dr. Paoletti (Laboratoire de Neurobiologie, CNRS). … | Get A Quote |
Precisely controlled synaptic glutamate concentration is essential for the normal function of the N-methyl D-aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results in the pathogenesis of neurological and psychiatric disorders. Therefore, glutamate concentration-dependent NMDA receptor modulators would be clinically useful agents with fewer on-target adverse effects. In the present study, we have characterized a novel compound (CNS4) that potentiates NMDA receptor currents based on glutamate concentration. This compound alters glutamate potency and exhibits no voltage-dependent effect. Patch-clamp electrophysiology recordings confi... More