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The E3 Ubiquitin Ligase TRIM25 Inhibits Tembusu Virus Replication

Front Vet Sci. 2021-09; 
Han Kaikai, Dongmin Zhao, Yuzhuo Liu, Qingtao Liu, Xinmei Huang, Jing Yang, Lijiao Zhang, Yin Li
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GenParts™ DNA Fragments … KY974316) was synthesized by GenScript (Nanjing, China) according to a specifically designed and codon-optimized sequence. DNA fragments were sub-cloned into the plasmid vector pcDNA3.1-c-myc (Life Technologies) utilizing the EcoR I/XhoI restriction enzymes. The … Get A Quote

摘要

Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused significant economic losses to the duck industry in China since 2010 due to egg production losses and neurological dysfunction. DTMUV is a public health concern because the infection spreads rapidly among birds. Retinoic acid-inducible gene-I (RIG-I)serves as an innate immune sensor and plays a key role in host antiviral defenses. Tripartite motif-containing protein 25 (TRIM25), an E3 ubiquitin ligase, is pivotal for RIG-I ubiquitination and activation. In addition, TRIM25 acts as an interferon-stimulated gene and mediates the antiviral activity. However, the effect of duck TRIM25 on DTMUV has not been assessed. Herein, we repo... More

关键词

TRIM25, Tembusu virus, duck, tissue distribution, viral replication