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Antibody signatures of asymptomatic Plasmodium falciparum malaria infections measured from dried blood spots

Malar J. 2021-09; 
Christine F Markwalter, Myat Htut Nyunt, Zay Yar Han, Ricardo Henao, Aarti Jain, Omid Taghavian, Philip L Felgner, Kay Thwe Han, Myaing M Nyunt, Christopher V Plowe
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Bacterial Expression … Malaria Journal volume 20, Article number: 378 (2021) Cite this article. 683 Accesses. 5 Altmetric … Briefly, exons from P. falciparum (strain 3D7) were cloned and expressed in individual T7 Escherichia coli-derived in vitro transcription/translation (IVTT) reactions (GenScript) … Get A Quote

摘要

background: Screening malaria-specific antibody responses on protein microarrays can help identify immune factors that mediate protection against malaria infection, disease, and transmission, as well as markers of past exposure to both malaria parasites and mosquito vectors. Most malaria protein microarray work has used serum as the sample matrix, requiring prompt laboratory processing and a continuous cold chain, thus limiting applications in remote locations. Dried blood spots (DBS) pose minimal biohazard, do not require immediate laboratory processing, and are stable at room temperature for transport, making them potentially superior alternatives to serum. The goals of this study were to assess the viability... More

关键词

Antibody responses, Asymptomatic malaria, Protein microarrays, Serology