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() Could Inhibit the Proliferation of Nucleopolyhedrovirus through Promoting Apoptosis

Insects. 2021-08; 
Jie Wang, Lin-Bao Zhu, Yan Ma, Ying-Xue Liu, Hui-Hua Cao, Yu-Ling Wang, Xue Kong, Zhi-Hao Huang, Han-Dan Zhu, Yan-Xiang Wang, Shi-Huo Liu, Jia-Ping Xu
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Recombinant Antibody Expression … After centrifugation at 12,000× g for 20 min at 4 C, the recombinant protein insoluble pellet was purified using High Affinity Ni-NTA Resin (GenScript, Nanjing, China), according to the manufacturer’s instructions. The quality of purified protein was analyzed by 12% sodium … Get A Quote

摘要

β-1,3-glucan recognition proteins (βGRPs) as pattern recognition receptors (PRRs) play an important role in recognizing various pathogens and trigger complicated signaling pathways in insects. In this study, we identified a β-1,3-glucan recognition protein gene named , which showed differential expression, from a previous transcriptome database. The full-length cDNA sequence was 1244 bp, containing an open reading frame (ORF) of 1128 bp encoding 375 amino acids. was strongly expressed in the larval stages and highly expressed in the midgut of larvae in particular. After BmNPV infection, the expression of was reduced significantly in the midgut. Furthermore, a significant increase in the copy number of Bm... More

关键词

B. mori nucleopolyhedrovirus, Bombyx mori, apoptosis, β-glucan recognition protein