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Vaccination against the Protozoan Parasite Primes the Activation of Toll-like Receptors in Turkeys and Chickens Determined by a Set of Newly Developed Multiplex RT-qPCRs

Vaccines (Basel). 2021-08; 
Taniya Mitra, Beatrice Bramberger, Ivana Bilic, Michael Hess, Dieter Liebhart
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … Biotech, Piscataway, NJ, USA) (www.genscript.com) with default settings. NCBI database and GenScript software were accessed on 4 December 2017 for TLR1A, 1B, 2A, 2B, 3 (Ch), 4, 5, 6 (Tu). The same database and software were used for TLR 3 (Tu), 7, 13 (Tu), 21 (Ch) on … Get A Quote

摘要

Histomonosis in turkeys and chickens is caused by the extracellular parasite , but the outcome of the disease varies depending on the host species. So far, studies on the immune response against histomonosis focus mainly on different traits of the adaptive immune system. Activation of toll like receptors (TLR) leads to the interplay between cells of innate and adaptive immunity with consequences on B and T cell clonal expansion. Therefore, the present investigation focused on the interaction of virulent and/or attenuated histomonads with the innate immune system of turkeys and chickens at 4, 10, 21 days post inoculation. The expression of TLRs (, , , , , , , (Tu), , (Tu) and (Ch)) and pro-inflammatory cytokines... More

关键词

blackhead disease, extracellular pathogen, histomonosis, innate immune response, poultry, pro-inflammatory cytokines