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Dynamic Changes in the Levels of Amyloid-β Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease

Front Mol Neurosci. 2021-08; 
Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo
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摘要

Although amyloid-β (Aβ) has been used as one of the core biomarkers for Alzheimer's disease (AD) diagnosis, the dynamic changes of its different forms in the brain, blood, and even intestines and its correlation with the progression of AD disease remain obscure. Herein, we screened Aβ-specific preferred antibody pairs 1F12/1F12 and 1F12/2C6 to accurately detect Aβ types using sandwich ELISA, including total Aβ, Aβ oligomers (AβOs), and Aβ monomers (AβMs). The levels of Aβ species in the brain, blood, and intestines of different aged APP/PS1 mice were quantified to study their correlation with AD progression. Total Aβ levels in the blood were not correlated with AD progression, but AβMs level in the ... More

关键词

Alzheimer’s disease, ELISA – enzyme-linked immunosorbent assay, blood Aβ42, dynamic distribution, intestinal Aβ