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Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells

J Mol Biol. 2021-08; 
Konrad Klockmeier, Eduardo Silva Ramos, Tamás Raskó, Adrián Martí Pastor, Erich E Wanker
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Molecular Biology Tools … (F) Analysis of the first 400 amino acids of ZNF804A using GenScript peptide property calculator tool. Indicated are the zinc-finger domain, as well as the three strong STAT2 peptide spotting regions from (E). Colors indicate polarity of amino acids; blue: basic residues (R, K and … Get A Quote

摘要

Previously evidence was presented that the single-nucleotide polymorphism rs1344706 located in an intronic region of the ZNF804A gene is associated with reduced transcript levels in fetal brains. This genetic variation in the gene encoding the zinc-finger protein ZNF804A is associated with schizophrenia (SZ) and bipolar disorder. Currently, the molecular and cellular function of ZNF804A is unclear. Here, we generated a high-confidence protein-protein interaction (PPI) network for ZNF804A using a combination of yeast two-hybrid and bioluminescence-based PPI detection assays, directly linking 15 proteins to the disease-associated target protein. Among the top hits was the signal transducer and activator of transc... More

关键词

ZNF804A protein–protein network, ZNF804A-STAT2 protein complex, interferon response, schizophrenia, signal transduction