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The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells

J Mol Med (Berl). 2021-08; 
Inah Camaya, Tsz Y Mok, Maria Lund, Joyce To, Nady Braidy, Mark W Robinson, Jerran Santos, Bronwyn O'Brien, Sheila Donnelly
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DNA Sequencing … A synthetic peptide corresponding to the sequence of the mature full-length native FhHDM-1 [18] was synthesised to 95% purity, with trifluoroacetic acid removed and determined to be endotoxin free (GenScript, USA). The structure of the synthetic version of the peptide had … Get A Quote

摘要

Type 1 diabetes (T1D) is an autoimmune disease characterised by the destruction of the insulin-producing beta (β)-cells within the pancreatic islets. We have previously identified a novel parasite-derived molecule, termed Fasciola hepatica helminth defence molecule 1 (FhHDM-1), that prevents T1D development in non-obese diabetic (NOD) mice. In this study, proteomic analyses of pancreas tissue from NOD mice suggested that FhHDM-1 activated the PI3K/Akt signalling pathway, which is associated with β-cell metabolism, survival and proliferation. Consistent with this finding, FhHDM-1 preserved β-cell mass in NOD mice. Examination of the biodistribution of FhHDM-1 after intraperitoneal administration in NOD mice r... More

关键词

Diabetes, Fasciola hepatica, Helminth defence molecule (FhHDM-1), PI3K-Akt pathway, β-Cell apoptosis