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Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation

Cell Death Dis. 2021-08; 
Zheyu Zhang, Zezhong Mou, Chenyang Xu, Siqi Wu, Xiyu Dai, Xinan Chen, Yuxi Ou, Yiling Chen, Chen Yang, Haowen Jiang
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DNA Sequencing … genes. We then found that knockdown of hsa_circ_0007813 led to altered cell autophagy, bringing our attention to IGF2R, one of the possible downstream genes. … Biotin-coupled hsa_circ_0007813 probes were designed and synthesized by Genscript (China) (Sequences of … Get A Quote

摘要

Circular RNAs (circRNAs) drive several cellular processes including proliferation, survival, and differentiation. Here, we identified a circRNA hsa_circ_0007813, whose expression was upregulated in bladder cancer. High hsa_circ_0007813 expression was associated with larger tumor size, higher primary tumor T stage, and higher pathologic grade. Survival analysis showed that patients with high hsa_circ_0007813 expression levels had a poorer prognosis. Based on these findings from clinical tissue samples and cell lines, we assumed that hsa_circ_0007813 functioned a vital role in bladder cancer progression. Next, functional experiments revealed that knockdown of hsa_circ_0007813 inhibited proliferation, migration, a... More

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