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miR‑101a‑3p overexpression prevents acetylcholine‑CaCl‑induced atrial fibrillation in rats via reduction of atrial tissue fibrosis, involving inhibition of EZH2

Mol Med Rep. 2021-08; 
Jing Zhu, Ning Zhu, Jian Xu
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Custom DNA/RNA Oligos … The primers utilized were supplied by GenScript, and their sequences were as follows: rno-miR-101a-3p forward, 5′-TACAGTACTGTGATAACTGAA−3′ and reverse: 5′-GCAGGGTCCGAGGTATTC−3′; and 5S forward, 5′-GATCTCGGAAGCTAAGCAGG-3′ and reverse, 5… Get A Quote

摘要

Atrial fibrillation (AF), a clinically common heart arrhythmia, can result in left ventricular hypofunction, embolism and infarction. MicroRNA (miR)‑101a‑3p is lowly expressed in atrial tissues of patients with AF, but its role in AF remains unknown. In the present study, an AF model in rats was established via intravenous injection of acetylcholine (Ach)‑CaCl. The downregulation of miR‑101a‑3p and upregulation of enhancer of zeste 2 homolog 2 (EZH2) were observed in AF model rats, indicating the involvement of miR‑101a‑3p and EZH2 in AF development. To study the effect of miR‑101a‑3p on AF , AF model rats were intramyocardially injected with lentivirus expressing miR‑101a‑3p. Electrocardi... More

关键词

atrial fibrillation, enhancer of zeste 2 homolog 2, fibrosis, microRNA‑101a‑3p, rats