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Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain

Front Cell Dev Biol. 2021-07; 
XiaoLuan Xu, AnQi Ma, TieSong Li, WenXue Cui, XueFeng Wang, Jun Li, Qingwei Li, Yue Pang
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Recombinant Antibody Expression … After four injections at 1 week intervals, blood was drawn from the mouse, and antibody purification was conducted using Protein A (GenScript, United States). The ELISA method was used to determine the antibody titers. Briefly, the rL-UCP2 protein was diluted with a coating … Get A Quote

摘要

During the process of vertebrate evolution, many thermogenic organs and mechanisms have appeared. Mammalian brown adipose tissue (BAT) generates heat through the uncoupling oxidative phosphorylation of mitochondria, acts as a natural defense against hypothermia and inhibits the development of obesity. Although the existence, cellular origin and molecular identity of BAT in humans have been well studied, the genetic and functional characteristics of BAT from lampreys remain unknown. Here, we identified and characterized a novel, naturally existing brown-like adipocytes at the lamprey brain periphery. Similar to human BAT, the lamprey brain periphery contains brown-like adipocytes that maintain the same morpholog... More

关键词

brown adipocytes, evolution, immune response, lamprey, uncoupling protein 2 (UCP2)