| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Library Services | … Two types of 7H peptides were purchased as HPLC-grade products (Genscript, Piscataway, NJ, USA); one has a cysteine residue added at the N-terminus (Cys-7H), while the other has cysteine attached to the C-terminus (7H-Cys). The 7H peptides were dissolved in 50 mM Tris… | Get A Quote |
Tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration and progressive supranuclear palsy as well as of Alzheimer's disease, and it has been a target for therapeutic development. Herein, we unexpectedly found that hepta-histidine (7H), an inhibitor of the interaction between Ku70 and Huntingtin proteins, suppresses aggregation of Tau-R3 peptides . Addition of the trans-activator of transcription (TAT) sequence (YGRKKRRQRRR) derived from the TAT protein to 7H increased its permeability into cells, and TAT-7H treatment of iPS cell-derived neurons carrying Tau or APP mutations suppressed Tau phosphorylation. These results indicate that 7H is a promising lead compound for dev... More
