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A -Derived Particulate Vaccine Protects against Infection

Vaccines (Basel). 2021-07; 
Zennia Jean C Gonzaga, Christina Merakou, Antonio DiGiandomenico, Gregory P Priebe, Bernd H A Rehm
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GenParts™ DNA Fragments … All DNA fragments were purchased from Genscript (Piscataway, NJ, USA). Primers were synthesized by Integrated DNA Technologies (IDT… The DNA fragments (GenScript) were excised by enzyme digestion, followed by fragment separation using agarose gel electrophoresis … Get A Quote

摘要

Despite numerous efforts to develop an effective vaccine against , no vaccine has yet been approved for human use. This study investigates the utility of the inherently produced polyhydroxyalkanaote (PHA) inclusions and associated host-cell proteins (HCP) as a particulate vaccine platform. We further engineered PHA inclusions to display epitopes derived from the outer membrane proteins OprF/OprI/AlgE (Ag) or the type III secretion system translocator PopB. PHA and engineered PHA beads induced antigen-specific humoral, cell-mediated immune responses, anti-HCP and anti-polysaccharide Psl responses in mice. Antibodies mediated opsonophagocytic killing and serotype-independent protective immunity as shown by 100% ... More

关键词

Pseudomonas aeruginosa, polyhydroxyalkanoate, protective immunity, vaccine