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Effect of Hydrophobicity and Charge Separation on the Antifouling Properties of Surface-Tethered Zwitterionic Peptides

Langmuir. 2021-07; 
Chuanxi Li, Minglun Li, Wei Qi, Rongxin Su, Jing Yu
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DNA Sequencing … All the zwitterionic peptides with a purity of >95% were obtained from Genscript (Nanjing, China). The molecular weights (MW) of different sequences were characterized by MALDI-TOF (Autoflex tof/tofIII, Bruker, USA) as shown in Figure S1. Tris(2-carboxyethyl)phosphine (TCEP… Get A Quote

摘要

Zwitterionic peptides emerge as a class of highly effective antifouling material in a wide range of applications such as biosensors, biomedical devices, and implants. We incorporated neutral amino acid spacers with different hydrophobicities, including serine (Ser), glycine (Gly), and leucine (Leu), into zwitterionic peptides with lysine-glutamic acid repeating units and investigated the structure and antifouling performance of the zwitterionic peptide brushes by surface plasma resonance, surface force apparatus (SFA), and all-atomistic molecular dynamics (MD) simulation techniques. Our results demonstrate that the hydrophilicity of neutral spacers alters the structure and antifouling performance of the peptide... More

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