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Tumor-promoting function of PIMREG in glioma by activating the β-catenin pathway

3 Biotech. 2021-07; 
Dekang Wang, Aili Hu, Hao Peng, Dongbo Li, Li Zhang
Products/Services Used Details Operation
DNA Sequencing … the optical density (OD) values at a wavelength of 450 nm were detected using a microplate reader (BioTek, USA) to evaluate cell viability. … The primers were synthesized by Genscript (China) and the primer sequences were: PIMREG forward, 5′-GTGCTTTGGGTGCCGTGTC-3… Get A Quote

摘要

Glioma is the most common primary brain tumor in adults with an adverse prognosis and obscure pathogenesis. PICALM interacting mitotic regulator protein (PIMREG) functions as an oncogene in multiple types of cancer, but its function in glioma remains unknown. The Gene Expression Profiling Interactive Analysis 2 (GEPIA2, http://gepia2.cancer-pku.cn/#index) showed that PIMREG expression in the glioma tissues was higher than that in normal brain tissues. Herein, cell counting kit-8 assay and flow cytometry analysis exhibited that overexpression of PIMREG significantly promoted the proliferation of glioma cells and the transition from G1 phase of the cell cycle to S phase. Wound-healing and transwell assays showed ... More

关键词

Cell invasion, Cell proliferation, Glioma, Oncogene, PIMREG, β-Catenin