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Effects of Lipidation on a Proline-Rich Antibacterial Peptide

Int J Mol Sci. 2021-07; 
Federica Armas, Adriana Di Stasi, Mario Mardirossian, Antonello A Romani, Monica Benincasa, Marco Scocchi
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Bacterial Expression … Lp-I was purchased from GenScript (Piscataway, NJ, USA) and purified to 90% purity by RP-HPLC [35]. Lipopeptides and Lp-I were dissolved in dimethyl sulfoxide (DMSO) following the manufacturer’s instructions. Any effects of DMSO on bacterial growth were excluded by … Get A Quote

摘要

The emergence of multidrug-resistant bacteria is a worldwide health problem. Antimicrobial peptides have been recognized as potential alternatives to conventional antibiotics, but still require optimization. The proline-rich antimicrobial peptide Bac7(1-16) is active against only a limited number of Gram-negative bacteria. It kills bacteria by inhibiting protein synthesis after its internalization, which is mainly supported by the bacterial transporter SbmA. In this study, we tested two different lipidated forms of Bac7(1-16) with the aim of extending its activity against those bacterial species that lack SbmA. We linked a C12-alkyl chain or an ultrashort cationic lipopeptide Lp-I to the C-terminus of Bac7(1-16... More

关键词

antibiotic resistance, antimicrobial agent, antimicrobial peptide, broad-spectrum activity, lipidation, lipopeptide, membrane permeabilization