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The PentaFOLD 30 Algorithm for the Selection of Stable Elements of Secondary Structure to be Included in Vaccine Peptides

Protein Pept Lett. 2021-01; 
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Insect Expression … To test the affinity of antibodies against the NY25 peptide we used recombinant hemagglutinin of pandemic H1N1 Influenza strain (GenScript product ACP41105.1; produced in Sf9 insect cells; completely glycosylated); to test the affinity of antibodies against the SF23 peptide … Get A Quote

摘要

objective: The aim of this study was to create a new version of the PentaFOLD algorithm and to test its performance experimentally in several proteins and peptides. background: Synthetic vaccines can cause production of neutralizing antibodies only in case if short peptides form the same secondary structure as fragments of full-length proteins. The Penta- FOLD 3.0 algorithm was designed to check stability of alpha helices, beta strands, and random coils using several propensity scales obtained during analysis of 1730 3D structures of proteins. objective: The algorithm has been tested in the three peptides known to keep the secondary structure of the corresponding fragments of full-length proteins: the NY25 pept... More

关键词

HIV1 gp120, SARS CoV-2, Synthetic vaccine, diphtheria toxin, hemagglutinin, human prion protein, secondary structure of proteins