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EHD2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Human Colon Cancer

Cancer Invest. 2021-01; 
Chengqi Guan, Cuihua Lu, Mingbing Xiao, Weichang Chen
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Polyclonal Antibody Services … Then, membranes were incubated in HRP-labeled goat anti‐rabbit IgG (H&L) polyclonal antibodies (GenScript, Nanjing, China, 1:4000) for 1 h at 4 °C overnight, and rinsed thrice in Tris‐buffered saline + Tween-20 (TBST) buffer … Get A Quote

摘要

To investigate how EHD2 influences the development of colon cancer. Immunohistochemistry of 90 colon cancer tissue specimens were determined the expression of EHD2. The lentivirus-EHD2-transfected colon cancer cells were conducted to evaluate the biological behaviors. EHD2 was closely associated with clinic pathological parameters ( < 0.001). EHD2 upregulation was relative with a longer overall survival. The results of the univariate and multivariate analyses indicated that EHD2 could be an independent prognosis marker. EHD2 overexpression suppressed cell invasion and proliferation, but enhanced cell apoptosis and cell cycle arrest. EHD2 might represent a therapeutic target of colon cancer.IMPACT STATEMENT ... More

关键词

EHD2, colon cancer, migration, prognosis