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In utero human cytomegalovirus infection is associated with increased levels of putatively protective maternal antibodies in nonprimary infection: evidence for boosting but not protection

Clin Infect Dis. 2021-02; 
Jeffrey R Dorfman, Sashkia R Balla, Jayani Pathirana, Michelle J Groome, Shabir A Madhi, Penny L Moore
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Monoclonal Antibody Services … Page 8. Accepted Manuscript 8 synthesized (Genscript, Piscataway, USA) from publicly available sequences, as previously described [28]. Monoclonal antibodies were biotinylated using an EZ-Link Sulfo-NHS-LC-Biotinylation Kit (Thermo Fisher, Waltham, USA) … Get A Quote

摘要

background: Although primary maternal cytomegalovirus infections are associated with higher risk of in utero transmission, most fetal infections worldwide result from nonprimary maternal infections. Antibodies directed at glycoprotein B and the gH/gL/pUL128-130-131 pentamer can neutralize virus, and higher levels of antibody directed at several particular pentamer epitopes defined by monoclonal antibodies (mAbs) are associated with reduced risk of fetal cytomegalovirus transmission during primary maternal infection. This had not been explored in maternal nonprimary infection. methods: In a setting where most maternal cytomegalovirus infections are nonprimary, 42 mothers of infants with congenital CMV infections... More

关键词

antibody, congenital infection, cytomegalovirus