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Position Effects Influence Transvection in

Genetics. 2019-10; 
Thomas D King, Justine E Johnson, Jack R Bateman
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Oligo pool … Oligopaint design and DNA-FISH. Oligopaint (oligo) probes (Beliveau et al. 2012) were designed for genomic regions surrounding insertions of P[TV2-GMR] at 22A, 42A, and 96F, and synthesized as a combined library by CustomArray, (Bothell, WA) … Get A Quote

摘要

Transvection is an epigenetic phenomenon wherein regulatory elements communicate between different chromosomes in , and is thereby dependent upon the three-dimensional organization of the genome. Transvection is best understood in , where homologous chromosomes are closely paired in most somatic nuclei, although similar phenomena have been observed in other species. Previous data have supported that the genome is generally permissive to enhancer action in , a form of transvection where an enhancer on one homolog activates gene expression from a promoter on a paired homolog. However, the capacity of different genomic positions to influence the quantitative output of transvection has yet to be addressed. To inve... More

关键词

chromatin, long-range enhancer, position effects, somatic homolog pairing, transvection