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Entropy-driven amplified electrochemiluminescence biosensor for RdRp gene of SARS-CoV-2 detection with self-assembled DNA tetrahedron scaffolds

Biosens Bioelectron. 2021-01; 
Zhenqiang Fan, Bo Yao, Yuedi Ding, Jing Zhao, Minhao Xie, Kai Zhang
Products/Services Used Details Operation
Custom DNA/RNA Oligos … oligonucleotides synthesized and purified by high-performance liquid chromatography (HPLC) method, were obtained from Genscript Biotechnology Co., Ltd … TBE) buffer and other analytical grade chemicals, unless otherwise specified, were obtained from Sangon Biotech Co … Get A Quote

摘要

Dependable, specific and rapid diagnostic methods for severe acute respiratory syndrome β-coronavirus (SARS-CoV-2) detection are needed to promote public health interventions for coronavirus disease 2019 (COVID-19). Herein, we have established an entropy-driven amplified electrochemiluminescence (ECL) strategy to detect the RNA-dependent RNA polymerase (RdRp) gene of SARS-CoV-2 known as RdRp-COVID which as the target for SARS-CoV-2 plays an essential role in the diagnosis of COVID-19. For the construction of the sensors, DNA tetrahedron (DT) is modified on the surface of the electrode to furnish robust and programmable scaffolds materials, upon which target DNA-participated entropy-driven amplified reaction is... More

关键词

DNA tetrahedron, Electrochemiluminescence sensor, Entropy-driven reaction amplification, RdRp-COVID, SARS-CoV-2