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Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK Inhibitors

Front Oncol. 2019-10; 
Elena Poddubskaya, Alexey Bondarenko, Alexander Boroda, Evgenia Zotova, Alex Glusker, Svetlana Sletina, Luidmila Makovskaia, Philipp Kopylov, Marina Sekacheva, Alexey Moisseev, Madina Baranova
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Oligo pool … Gene expression profiling was performed using microarray platform CustomArray (USA) according to the Manufacturer's protocol, except for the addition of the dNTP mix containing biotinylated dUTP to the amplification reaction (final proportion of dTTP/biotin-dUTP was 5-to-1) … Get A Quote

摘要

Non-small cell lung carcinoma (NSCLC) is the major cause of cancer-associated mortality. Identification of rearrangements in anaplastic lymphoma kinase () gene is an effective instrument for more effective targeted therapy of NSCLC using ALK inhibitors dramatically raising progression-free survival in the mutated group of patients. However, the tumors frequently develop resistance to ALK inhibitors. We describe here a case of 48 y.o. male patient with -positive NSCLC who was clinically managed for 6.5 years from the diagnosis. The tumor was surgically resected, but 8 months later multiple brain metastases were discovered. The patient started receiving platinum-based chemotherapy and then was enrolled in a clini... More

关键词

ALK, NSCLC, gene expression, personalized oncology, transcriptomics