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Proteome Analyses Reveal S100A11, S100P, and RBM25 Are Tumor Biomarkers in Colorectal Cancer

Proteomics Clin Appl. 2020-11; 
Ai-Jun Guo, Feng-Jie Wang, Qiang Ji, Hui-Wu Geng, Xu Yan, Lin-Qi Wang, Wei-Wei Tie, Xiao-Ying Liu, Rick F Thorne, Gang Liu, A-Man Xu
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Protein Tools … each sample. Subcellular localization of hits was predicted using Wolfpsort v.0.2, an updated version of PSORT/ PSORT II, (http://www.genscript.com/psort/wolf_psort.html). DEPs between and among groups were analyzed using the R vegan package (Version 2.0-2; … Get A Quote

摘要

purpose: The prognosis for colorectal cancer (CRC) patients is drastically impacted by the presence of lymph node or liver metastases at diagnosis or resection. On this basis it is sought to identify novel proteins as biomarkers and determinants of CRC metastasis. experimental design: Proteomic analyses are undertaken using primary tissues from ten Chinese CRC patients presenting with or without liver metastases and immunohistochemistry used to validate selected proteins in an independent patient cohort. results: Comparing CRC against paired normal adjacent tissues identifies 1559 differentially expressed proteins (DEPs) with 974 upregulated and 585 downregulated proteins, respectively. The highest number of DE... More

关键词

RBM25, S100A11, S100P, colorectal cancer (CRC), differentially expressed proteins (DEP)