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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Clin Infect Dis. 2021-02;

Natalie Lorenz, Timothy Kc Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland

Products/Services Used	Details	Operation
Catalog Antibody	… corresponding to the 50 amino acids of N-terminal hypervariable region of the mature M-protein (Supplementary Table 3) were commercially synthesised to >90% purity (GenScript Inc.). Detection of Serum Antibodies and Statistical Analysis …	Get A Quote

摘要

Rheumatic fever is a serious post-infectious sequela of Group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.