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Immunization with Aβ3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg-APPswe/PSEN1dE9 mice

Brain Res Bull. 2021-05; 
Xiao-Yi Zhang, Yuan Meng, Xue-Jing Yan, Shuo Liu, Guo-Qing Wang, Yun-Peng Cao
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Neoantigen Peptide Service … 2. Materials and methods. 2.1. Vaccine synthesis. The vaccine that we used in this research, Aβ3-10-KLH, was produced by GenScript Co., Ltd. (Nanjing, China). The amino acid sequence of Aβ3-10 is H-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-COOH … Get A Quote

摘要

Alzheimer's disease is a common cause of dementia, for which no disease-modifying therapy is yet available. Aβ3-10-KLH, a vaccine for active immunization, has been shown to prevent pathological changes in young transgenic models of AD, but the effects of treatment with it and its effects on mitochondrial dysfunction remain unclear. We immunized 6-month-old Tg-APPswe/PSEN1dE9 mice with Aβ3-10-KLH to analyze whether it is capable of eliminating amyloid-β after its appearance. The vaccine effectively decreased amyloid-β deposits, improved cognitive function and ameliorated mitochondrial dysfunction. These results indicate the potential of Aβ3-10-KLH as a vaccine to treat AD.

关键词

Alzheimer’s disease, Amyloid-β, Aβ3-10-KLH vaccine, Mitochondrial dysfunction