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Secreted Expression of mRNA-Encoded Truncated ACE2 Variants for SARS-CoV-2 via Lipid-Like Nanoassemblies

Adv Mater. 2021-08; 
Min Li, Sanpeng Li, Yixuan Huang, Haixia Chen, Songya Zhang, Zhicheng Zhang, Weigang Wu, Xiaobin Zeng, Boping Zhou, Bin Li
Products/Services Used Details Operation
Custom DNA/RNA Oligos TAMRA‐labeled oligos and SARS‐CoV‐2 Surrogate Virus Neutralization Test Kit were ordered from Genscript. Get A Quote

摘要

The transfer of foreign synthetic messenger RNA (mRNA) into cells is essential for mRNA-based protein-replacement therapies. Prophylactic mRNA COVID-19 vaccines commonly utilize nanotechnology to deliver mRNA encoding SARS-CoV-2 vaccine antigens, thereby triggering the body's immune response and preventing infections. In this study, a new combinatorial library of symmetric lipid-like compounds is constructed, and among which a lead compound is selected to prepare lipid-like nanoassemblies (LLNs) for intracellular delivery of mRNA. After multiround optimization, the mRNA formulated into core-shell-structured LLNs exhibits more than three orders of magnitude higher resistance to serum than the unprotected mRNA, a... More

关键词

SARS-CoV-2; lipid-like nanoassemblies; messenger RNA; spleen-targeted delivery systems; truncated ACE2 decoys.