至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

Cell Reports. 2022-12; 
Alhaji H. Janneh, Mohamed Faisal Kassir, F. Cansu Atilgan, Stephen Tomlinson, Shikhar Mehrotra, Besim Ogretmen
Products/Services Used Details Operation
Catalog Antibody THETM DYKDDDDK Tag Antibody [HRP],mAb, Mouse ,GenScript Cat# A01428, RRID:AB_1720817; Plasmid: Mouse S1pr1(NM_007901.5)ORF Clone, pcDNA3.1+/C-(K) DYK,GenScript Cat# OMu20424D; Get A Quote
Plasmid DNA Preparation Get A Quote

摘要

Crosstalk between metabolic and signaling events that induce tumor metastasis remains elusive. Here, we determine how oncogenic sphingosine 1-phosphate (S1P) metabolism induces intracellular C3 complement activation to enhance migration/metastasis. We demonstrate that increased S1P metabolism activates C3 complement processing through S1P receptor 1 (S1PR1). S1P/S1PR1-activated intracellular C3b-a0 2 is associated with PPIL1 through glutamic acid 156 (E156) and aspartic acid 111 (D111) residues, resulting in NLRP3/ inflammasome induction. Inactivation mutations of S1PR1 to prevent S1P signaling or mutations of C3b-a0 2 to prevent its association with PPIL1 attenuate inflammasome activation and reduce lun... More

关键词