Products/Services Used | Details | Operation |
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Custom Vector Construction> | … each year in the US 6 . The cost of rabies PEP varies greatly in the US and around the world, … synthesized (GenScript Inc) and cloned into IgG1 expression vectors as described above. … | Get A Quote |
Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), a passive component of rabies post-exposure prophylaxis (PEP), with a monoclonal antibody (MAb), would eliminate the cost and availability constraints associated with RIG. Our team has developed and licensed a human monoclonal antibody RAB1 (Rabishield), as the replacement for RIG where canine rabies is enzootic. However, for the highly diverse rabies viruses of North America, a cocktail containing two or more MAbs targeting different antigenic sites of the rabies glycoprotein should be included to ensure neutralization of all variants of the virus. In this study, two MAb cocktails, R17... More