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miR-29c-3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

Genes Cells. 2021-07; 
Ruili Wang, Jie Yao, Fuhua Gong, Songsheng Chen, Ya He, Chunting Hu, Chen Li
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Custom DNA/RNA Oligos … The sequences of primers of TET2 (Genscript) utilized in qRT… to obtain the targeted binding sequence between miR-29c-3p … ’-UTR of TET2 containing binding sequences for miR-29c-3p … Get A Quote

摘要

Autophagy in dopamine (DA) neurons is concerned to be associated with Parkinson's disease (PD), but the detailed mechanism remains unknown. Herein, we aimed to investigate the function of microRNA (miR)-29c-3p in autophagy in PD models. Intraperitoneal injection of MPTP (20 mg/kg) was given to C57BL/6 mice to establish PD mouse model. SH-SY5Y cells were treated with MPP (1 mmol/L) to establish in vitro PD model. The results indicated that in the substantia nigra pars compacta (SNpc) DA neurons of PD mice, autophagy was activated accompanied by down-regulated miR-29c-3p and up-regulated ten-eleven translocation 2 (TET2) expression. Up-regulation of miR-29c-3p inhibited TET2 expression and SNpc (including DA ne... More

关键词

Parkinson disease, TET2, autophagy, dopaminergic neuron, microRNA-29c-3p