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Limited Impact of Delta Variant's Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Viruses. 2021-11; 
Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino
Products/Services Used Details Operation
Catalog Antibody … To determine the neutralizing activity of antibodies against SARS-CoV-2, we used a surrogate viral neutralization test (C-Pass GenScript sVNT, Piscataway, NJ, USA) according to the … Get A Quote

摘要

The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the ... More

关键词

COVID-19 vaccine, SARS-CoV-2, neutralization, protection, serology