至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues

Bioorg Med Chem. 2022-09; 
Sinan Gai, Kajitha Suthagar, Karl J Shaffer, Wanting Jiao, Yacoba V T Minnow, Kayla Glockzin, Sean W Maatouk, Ardala Katzfuss, Thomas D Meek, Vern L Schramm, Peter C Tyler
Products/Services Used Details Operation
Custom Vector Construction … Q4DRC3) was codon-optimized for expression in Escherichia coli, synthesized, and cloned into a pET-28a(+) expression vector using NdeI and HindIII restriction sites (GenScript, USA), … Get A Quote

摘要

Phosphate groups play essential roles in biological processes, including retention inside biological membranes. Phosphodiesters link nucleic acids, and the reversible transfer of phosphate groups is essential in energy metabolism and cell-signalling processes. Phosphorylated metabolic intermediates are known targets for metabolic and disease-related disorders, and the enzymes involved in these pathways recognize phosphate groups in their catalytic sites. Therapeutics that target these enzymes can require charged (ionic) entities to capture the binding energy of ionic substrates. Such compounds are not cell-permeable and require pro-drug strategies for efficacy as therapeutics. Protozoan parasites such as Plasmo... More

关键词