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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens

Front Immunol. 2022-03; 
David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M Posavad
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ORF cDNA Clones/MolecularCloud … predicted HLA binding affinity were synthesized (Genscript). Single peptides from reactive … HSV ORFs, at the possible expense of missing rare responses. Previous measures of blood or … Get A Quote

摘要

Antigen-specific T persist and protect against skin or female reproductive tract (FRT) HSV infection. As the pathogenesis of HSV differs between humans and model organisms, we focus on humans with well-characterized recurrent genital HSV-2 infection. Human CD8+ T persisting at sites of healed human HSV-2 lesions have an activated phenotype but it is unclear if T can be cultivated . We recovered HSV-specific T from genital skin and ectocervix biopsies, obtained after recovery from recurrent genital HSV-2, using activation by viral antigen. Up to several percent of local T cells were HSV-reactive CD4 and CD8 T cell lines were up to 50% HSV-2-specific after sorting-based enrichment. CD8 T displayed HLA-restricte... More

关键词

CD4, CD8, HSV-2, dendritic cell, epitope, female reproductive tract immunology