Products/Services Used | Details | Operation |
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Plasmid DNA Preparation> | … All plasmids used the pcDNA3.1 + vector (GenScript) and were verified by Sanger … calculated using Microsoft Excel, and graphed using GraphPad Prism 9.1.1 (225) software. … | Get A Quote |
Since the emergence of SARS-CoV-2, five different variants of concern (VOCs) have been identified: Alpha, Beta, Gamma, Delta, and Omicron. Due to confounding factors in the human population, such as pre-existing immunity, comparing severity of disease caused by different VOCs is challenging. Here, we investigate disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 VOCs. Disease severity in rhesus macaques inoculated with Omicron BA.1 or BA.2 was lower than those inoculated with Delta and resulted in significantly lower viral loads in nasal swabs, bronchial cytology brush samples, and lung tissue in rhesus macaques. Cytokines and chemokines were upregula... More