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Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Nat Ecol Evol. 2022-10; 
Phillip L Davidson, Haobing Guo, Jane S Swart, Abdull J Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, Hannah R Devens, Demian Koop, Paula Cisternas, He Zhang, Yaolei Zhang, Maria Byrne, Guangyi Fan, Gregory A Wray
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PCR Cloning and Subcloning … The full-length HesC coding sequence was synthesized in vitro by GenScript (Piscataway, NJ, USA) and subcloned (NCBI insert number: MK749159), and used as template to make … Get A Quote

摘要

Changes in developmental gene regulatory networks (dGRNs) underlie much of the diversity of life, but the evolutionary mechanisms that operate on regulatory interactions remain poorly understood. Closely related species with extreme phenotypic divergence provide a valuable window into the genetic and molecular basis for changes in dGRNs and their relationship to adaptive changes in organismal traits. Here we analyse genomes, epigenomes and transcriptomes during early development in two Heliocidaris sea urchin species that exhibit highly divergent life histories and in an outgroup species. Positive selection and chromatin accessibility modifications within putative regulatory elements are enriched on the branch ... More

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